Immunopathology & Immunotherapy

OBJETIVOS:
Reciclaje y actualización de profesionales de la inmunología clínica en el campo de los trasplantes.
•    Repasar las pruebas diagnósticas inmunológicas para el Diagnóstico y Seguimiento de diferentes tipos de Trasplantes (de órganos sólidos y hematopoyéticos).
•    Conocer las presentaciones clínicas de las patologías de más frecuentes asociadas a los trasplantes de órganos.
•    Entender la correlación de las manifestaciones clínicas con las pruebas analíticas en trasplantes.
•    Ser capaces de emitir un informe diagnóstico de calidad, preciso y entendible para los clínicos.
•    Ser capaces de proponer posibles Inmunoterapias de algunas situaciones pre- y post-trasplante estudiadas.

Paolo Sfrisoa, , ,Francesco Casoa,Sofia Tognonb,Paola Galozzia,Alessandra Gavaa,Leonardo Punzia

a Rheumatology Unit, Department of Medicine, University of Padova, Padova, Italyb Ophthalmology Unit, Department of Neurosciences, University of Padova, Padova, Italy

http://dx.doi.org/10.1016/j.autrev.2012.07.028,

Blau syndrome (BS) is a rare autosomal dominant, autoinflammatory syndrome characterized by the clinical triad of granulomatous recurrent uveitis, dermatitis and symmetric arthritis. The gene responsible for BS has been identified in the caspase recruitment domain gene CARD15/NOD2. In the majority of patients, the disease is characterized by early onset, usually before 3–4 years of age. The manifestations at disease onset are usually represented by articular and cutaneous involvement signs, generally followed later by ocular manifestations which are often the most relevant morbidity of BS. In some cases the presence of fever is also observed; atypical cases of BS have been reported with cardiovascular, neurological, renal, intestinal and other organ involvement. The rarity and the variations in the severity and evolution of its expressions do not permit sufficient data about optimal treatment for patients with BS. The first step of therapy is represented by the use of corticosteroids and successively, in case of unsatisfactory response, by additional treatment with immunosuppressive agents. The results with biologic anti-cytokine agents, such as anti-TNFα and anti-IL1β, are different, particularly with regard to ocular morbidity. Clinical and genetic aspects of the familial and the sporadic form of BS will be discussed and focused on. A description of a case study of an Italian family is also included.

Blau syndrome, clinical and genetic aspects http://t.co/BALw5P69...

OBJETIVOS:
•    Repasar las pruebas diagnósticas Inmunológicas para el Diagnóstico y Seguimiento de Enfermedades Autoinmunes no-órgano-específicas.
•    Conocer las presentaciones clínicas de las patologías de Autoinmunes sistémicas más frecuentes.
•    Entender la correlación de las manifestaciones clínicas con las pruebas analíticas en estas enfermedades.
•    Ser capaces de emitir un informe diagnóstico de calidad, preciso y entendible para los clínicos.
•    Ser capaces de proponer el abordaje terapéutico de las patologías diagnosticadas.

The pathogenesis of systemic lupus erythematosus—an update

Jinyoung Choi1, *,Sang Taek Kim1, *,Joe Craft1, 2,

1 Department of Internal Medicine (Rheumatology), Yale School of Medicine, New Haven, CT 06520, United States2 Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, United States

http://dx.doi.org/10.1016/j.coi.2012.10.004,

Systemic lupus erythematosus (SLE, lupus) is characterized by a global loss of self-tolerance with activation of autoreactive T and B cells leading to production of pathogenic autoantibodies and tissue injury. Innate immune mechanisms are necessary for the aberrant adaptive immune responses in SLE. Recent advances in basic and clinical biology have shed new light on disease mechanisms in lupus, with this review discussing the recent studies that offer valuable insights into disease-specific therapeutic targets.

The pathogenesis of systemic lupus erythematosus—an update [Current Opinion in Immunology—an update] http://t.co/gKMERgRK...