A novel innate ANTIBIOTIC discovered in animal cells. Potential therapeutic role if demonstrated in humans | Immunology for University Students | Scoop.it
From www.ncbi.nlm.nih.gov - November 15, 2012 5:22 AM

A novel role for lipid droplets in the organismal antibacterial response

Preetha Anand,1,† Silvia Cermelli,1,† Zhihuan Li,2 Adam Kassan,3 Marta Bosch,3 Robilyn Sigua,1 Lan Huang,1,4 Andre J Ouellette,5 Albert Pol,3,6 Michael A Welte,2 and Steven P Gross1,*

 

We previously discovered histones bound to cytosolic lipid droplets (LDs); here we show that this forms a cellular antibacterial defense system. Sequestered on droplets under normal conditions, in the presence of bacterial lipopolysaccharide (LPS) or lipoteichoic acid (LTA), histones are released from the droplets and kill bacteria efficiently in vitro. Droplet-bound histones also function in vivo: when injected into Drosophila embryos lacking droplet-bound histones, bacteria grow rapidly. In contrast, bacteria injected into embryos with droplet-bound histones die. Embryos with droplet-bound histones displayed more than a fourfold survival advantage when challenged with four different bacterial species. Our data suggests that this intracellular antibacterial defense system may function in adult flies, and also potentially in mice.

DOI: http://dx.doi.org/10.7554/eLife.00003.001

 

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